Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - AP 18

AP 18

CAS No. 55224-94-7

AP 18 ( —— )

Catalog No. M27426 CAS No. 55224-94-7

AP 18 is a selective TRPA1 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 Get Quote
5MG 65 Get Quote
10MG 102 Get Quote
25MG 215 Get Quote
50MG 340 Get Quote
100MG 533 Get Quote
500MG 1143 Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AP 18
  • Note
    Research use only, not for human use.
  • Brief Description
    AP 18 is a selective TRPA1 inhibitor.
  • Description
    AP 18 is a selective TRPA1 inhibitor.(In Vitro):At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes.(In Vivo):AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity .
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    phospholipase A2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55224-94-7
  • Formula Weight
    209.7
  • Molecular Formula
    C11H12ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C(C)=CC1=CC=C(Cl)C=C1)=NO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9).
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Probenecid

    The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.

  • Pyr6

    Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?

  • L-R4W2

    Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.

Sign In Join Free