Cart
sales@molnova.com
AP 18
CAS No. 55224-94-7
AP 18 ( —— )
Catalog No. M27426 CAS No. 55224-94-7
AP 18 is a selective TRPA1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 102 | Get Quote |
|
| 25MG | 215 | Get Quote |
|
| 50MG | 340 | Get Quote |
|
| 100MG | 533 | Get Quote |
|
| 500MG | 1143 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAP 18
-
NoteResearch use only, not for human use.
-
Brief DescriptionAP 18 is a selective TRPA1 inhibitor.
-
DescriptionAP 18 is a selective TRPA1 inhibitor.(In Vitro):At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes.(In Vivo):AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity .
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
Recptorphospholipase A2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number55224-94-7
-
Formula Weight209.7
-
Molecular FormulaC11H12ClNO
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C(C)=CC1=CC=C(Cl)C=C1)=NO
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9).
molnova catalog
related products
-
K 0859
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
-
SAR7334
SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
-
RN-1747
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: hTRPV4 of 0.77 μM, mTRPV4 of 4.0 μM, and rTRPV4 of 4.1 μM). RN-1747 also antagonizes TRPM8 (IC50: 4 μM).
